HDAC6 KD differentially regulates p-MTOR and the tuberous sclerosis complex in MDA-MB-231 and MDA-MB-468 breast cancer cells. (a-d) MDA-MB-231 and MDA-MB-468 cells were subjected to western blot analysis for (a) p-MTOR, MTOR, (b) p-AKT, AKT, (c) TSC1, TSC2, (d) p-RPS6KB and p-EIF4EBP1.