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Autophagy promotes aging in a gender-specific manner in C. elegans. High autophagy in the gut (blue) allows adult C. elegans hermaphrodites (left) to produce more yolk and maximize reproductive output. However, it leads to senescent gut atrophy (red) and yolk steatosis (orange). This is driven by an IIS-activated reproductive program that is repressed in males (right) by mab-3 activity.
