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. 2019 May 17;7:e6949. doi: 10.7717/peerj.6949

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©2019 Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

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The q-value < 0.05 and fold change >2 were used to identify differentially expressed mRNAs and lncRNAs in OYL. Gene Ontology (GO) enrichment analyses were performed to analyze the functional enrichment of differentially expressed mRNAs and lncRNAs. (A) Differentially expressed mRNAs in OYL. (B) Differentially expressed lncRNAs in OYL. (C) Functional enrichment analysis for up-regulated mRNAs in OYL. (D) Functional enrichment analysis for down-regulated mRNAs in OYL. (E) Function enrichment analysis for the target genes of up-regulated lncRNAs in OYL. (F) Function enrichment analysis for the target genes of down-regulated lncRNAs in OYL. Only the most enriched (p < 0.05) and meaningful GO terms are presented here. OYL, old liver vs. young liver; red dots and blue dots represent up-regulated and down-regulated mRNAs during aging, respectively. FDR, false discovery rate; FC, fold change. BP, biological process; CC, cellular component; MF, molecular function.