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. Author manuscript; available in PMC: 2020 Jun 5.
Published in final edited form as: Eur J Pharmacol. 2019 Mar 28;852:218–230. doi: 10.1016/j.ejphar.2019.03.038

Fig. 3. GPR4 antagonist 13 reduces VCAM-1 protein expression in colon microvascular endothelial cells.

Fig. 3.

VCAM-1 protein expression intensity was assessed by immunohistochemistry (IHC) in colon microvascular endothelial cells. Representative pictures of vehicle distal (A), middle (C), and proximal (E) colon segments compared to GPR4 antagonist 13 distal (B), middle (D), and proximal (F) colon segments followed by graphical representation of VCAM-1 intensity score (G). Vehicle: N=21 (10 male/11 female) and GPR4 antagonist 13: N=19 (10male/9 female). Data are presented as mean ± S.E.M. and was analyzed for statistical significance using the t-test between vehicle and GPR4 antagonist 13 groups between each colon segment. (**P < 0.01). 40× objective. Scale bar = 100μm. Black arrows indicate blood vessels.