Table 3.
The rate of derivatives and drug-resistance generation. The day of the 1st derivative appearance was confirmed according to developed method I for CIP and AML and method II for GN and TN, described in the Materials and Methods. The day of the first resistance of particular derivatives was confirmed via the disc diffusion method. The total number of all selected derivatives represents the strains expressing antibiotic-tolerance >MIC of ciprofloxacin (CIP), amoxicillin (AML), gentamycin (GN), or tobramycin (TN).
| Day of first derivative/Day of first resistance/Total number of selected derivatives generated by: |
||||
|---|---|---|---|---|
| E. coli wild type | CIP | AML | GN | TN |
| 1 | 1/1/7 | 2/2/9 | 4/8/5 | 4/6/6 |
| 5 | 1/1/7 | 2/2/9 | 3/0/5 | 3/5/6 |
| 6 | 1/1/7 | 2/5/8 | 5/0/4 | 4/6/6 |
| 16 | 1/1/7 | 2/13/8 | 3/7/5 | 3/7/6 |
| 84 | 0/0/0 | 6/0/8 | 3/0/3 | 6/0/5 |