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. 2019 Mar 28;10(1):234–247. doi: 10.1080/21505594.2019.1596505

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — TptA deficiency attenuates virulence of A. fumigatus in a murine model of invasive aspergillosis. (a) Survival of highly immunosuppressed mice treated with cyclophosphamide and cortisone acetate and infected with the indicated A. fumigatus strains. (b) Survival of cortisone acetate-treated mice infected with the indicated A. fumigatus strains. Data are the combined from two independent experiments for a total of 16 mice per strain (n = 16). Statistical differences for mouse survival were calculated using the Log-Rank (Mantel-Cox) test. (c) Pulmonary fungal burden in cortisone acetate-treated mice infected with the indicated strains, as measured by determination of pulmonary galactomannan content (n = 8). Values are medians plus interquartile range (error bars). Statistical differences were calculated using t test. (d) Pulmonary histopathology sections from cortisone acetate-treated mice infected with the indicated strains and stained with PAS for visualization of fungal elements (black arrows). Bar = 200 μM.