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. 2019 May 6;10(1):133–141. doi: 10.1080/21655979.2019.1607709

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© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Effect of inhibition of S100A9 mRNA on the invasive potential of MG63 (A and B) and U2OS (C) cells. For invasion assays, cells transfected with siRNA were seeded in a cell migration chamber with the inner well coated with Matrigel (40 ug for MG63, 20ug for U2OS) and incubated for 48 h (MG63) or 72 h (U2OS). The number of cells invading through the Matrigel-coated membrane was then counted. (a) Representative photomicrographs of MG63 cells treated with control siRNA (a), siRNA1 against S100A9 (b), and siRNA2 against S100A9 (c). Original magnification, ×100. (b) There were significant differences in the number of invading cells between the groups (P = 0.026, control siRNA versus siRNA1 against S100A9; P = 0.017, control siRNA versus siRNA2). (c) Representative photomicrographs of U2OS cells transfected with control siRNA (a) or siRNA2 against S100A9 (b). Original magnification, ×100.There was a significant difference between the two groups (P = 0.002).