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Potential mechanisms underlying the relationship between hypertension and AD. The vascular damage produced by hypertension leads to brain dysfunction thought hypoxia-ischemia, as well as increase in Aβ production due to increased APP processing by secretase enzymes and reduced clearance of AD-related proteins. In turn, Aβ and tau alter vascular function amplifying the deleterious vascular impact of hypertension (reproduced from ref.8 with permission). (Illustration Credit: Ben Smith).
