Source: Adapted from Pandey et al., 2015 (26). For reference, shown are the lower end (red arrows and dotted line) and upper bounds (green arrows and dotted line) of the 2008 Guidelines for moderate-to-vigorous physical activity. Also indicated is the moderate-to-vigorous physical activity amount associated with normalization of the risk from >8h per day of sedentary activity from Ekelund et al., 2016 (8) (gold arrows and dotted line). The latter would represent the amount of physical activity required to compensate for a highly sedentary lifestyle. Note, the colors of the arrows are important, not the direction of the arrow.