Figure 6.

Synergy of DHA and CQ with recombinase inhibitor B02. A and B, isobologram of DHA–B02 combination in 3D7 and Dd2 strains, respectively. C and D, isobologram of CQ–B02 combination in 3D7 and Dd2 strains, respectively. Fixed-ratio drug combination assays were performed. FIC, fraction inhibitory concentration. Each point represents the mean IC₅₀ of drug combination from three independent experiments. The solid line is plotted between the IC₅₀ values of each drug when used alone to emphasize the concave nature of the isobolograms.