Figure 1.

Codon bias–normalized amino acid frequencies of human and rat MASP-2–selected TFPI1 D2 variants. A, codon bias–normalized sequence logo of human MASP-2 binding clones. B, codon bias–normalized sequence logo of rat MASP-2–binding variants. A and B, positions are labeled according to the Schechter–Berger nomenclature above each column. The height of each column represents the degree of conservation. The cysteine at P2 was not randomized; therefore, it shows the maximal column height. Letter heights indicate normalized amino acid frequencies. Colors reflect the chemical properties of the amino acid side chains.