Figure 2.
Schematic representation of the Raetz pathway for the synthesis of Kdo2-lipid A. Shown is the pathway as operative in E. coli K-12 according to Ref. 1. The pathway is composed of nine conserved enzymes located in the cytoplasm or the cytoplasmic membrane. The chemical structure of substrates and products of the reactions is indicated. From the top left, arrows show the order of reactions, and the corresponding enzymes are colored according to the resulting structural modification of the product. Where appropriate, the names of substrates or products are specified.