Table 1.

Effect of different concentrations of indomethacin on human gastric cancer cell proliferation and viability

AGS cells were treated with indomethacin at the indicated doses for 24 h. Cells were analyzed for DNA content and cellular dehydrogenase activity as described under “Experimental procedures.” All experiments were done in triplicate. Data are presented as means ± S.D. **, p < 0.01; ***, p < 0.001 versus indomethacin 0 mm.

Sample	[3H]Thymidine incorporation (counts/min)	Cellular dehydrogenase activity (MTT reduction, OD570 nm)
Indomethacin 0 mm	87,859.0 ± 6505.9	0.93 ± 0.03
Indomethacin 0.25 mm	28,501.7 ± 4132.7***	0.65 ± 0.02**
Indomethacin 0.50 mm	16,130.3 ± 2344.8***	0.48 ± 0.02***
Indomethacin 0.80 mm	7319.7 ± 428.5***	0.26 ± 0.01***
Indomethacin 1.5 mm	3515.0 ± 472.7***	0.18 ± 0.01***