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. 2019 Mar 29;294(20):8015–8022. doi: 10.1074/jbc.RA119.007928

Figure 3.

Figure 3.

A view of the open entrance channel of the apo 3A5 active site with testosterone docked in the channel (A) and the closed entrance channel in apo 3A4 (B) that reflects the lower trajectory of F–F′ connector and interactions of Phe-107, Phe-215, and Phe-220 with Phe-213. The testosterone pose overlaps two glycerol molecules seen in the apo 3A5 structure (Fig. S1). The docking pose was identified by using Autodock Vina. The distance from testosterone (TES) to the heme iron is 16.7 Å. Amino acid residues that differ between 3A4 and 3A5 are identified by bold labels.