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. 2019 May 20;14(5):e0216527. doi: 10.1371/journal.pone.0216527

Fig 15. Immunolabeling among human-like pre-cNF in mice with SC-conditional Nf1/Nf1 mutations.

Fig 15

A-E: Hair follicles (hf) from the dorsum of the foot–some are engulfed in dense fine-caliber aberrant innervation (arrowheads). S = sebaceous gland. A. PGP labeling (red arrowheads) of innervation fully engulfing a follicle. B, C. Some follicles with normal innervation are shown to the left and a partially engulfed follicle to the right. Normal innervation with and without CGRP co-labeling of PGP is present in the upper dermis and neck of the hair follicle (yellow and green arrowheads), as well as normal pilo-neural innervation (broad arrows) located just below the follicle sebaceous glands. D, E. Some follicles with normal innervation are shown to the left and two follicles to the right partially in dense aberrant innervation (arrow head). Normal innervation is seen with and without NF200 (yellow and green arrows). The pilo-neural complexes have a mix of endings with and without NF200 (yellow and green striped arrows). F. Sweat gland with normal PGP-labeled innervation (red arrows). G. Nf1/Nf1 sweat gland with dense aberrant innervation (red arrowheads). H, I. An arteriole with normal innervation labeled only for PGP (green arrow) and double-labeled for CGRP and PGP (yellow arrows). J.K. An Nf1/Nf1 arteriole engulfed in dense aberrant innervation (green arrowhead), but with some normal CGRP innervation (yellow arrows). Scale bar = 50μm.