Medians of minimum estimates of mutation load assigned to ggCg to ggTg (A) and gCg to gTg (B) signatures are depicted as bars. Gray circles represent minimum mutation load for each individual cancer genome sample. Whiskers of the bars represent standard errors. See also S1 Data. BLCA, bladder urothelial carcinoma; BLCA, breast invasive carcinoma; CRC, colorectal carcinoma; GBM, glioblastoma multiforme; HNSC, head and neck squamous cell carcinoma; KICH, kidney chromophobe; KIRC, kidney renal clear cell carcinoma; LGG, brain lower-grade glioma; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; PRAD, prostate adenocarcinoma; SKCM, skin cutaneous melanoma; THCA, thyroid carcinoma; UCEC, uterine corpus endometrial carcinoma.