Table 4.
Summary of the prognostic value of different TIL phenotypes on OS in different types of melanoma. CM (cutaneous melanoma), UM (uveal melanoma), Melanoma (M) was defined as the type of melanoma that is not explicitly stated in the studies.
| TIL phenotypes | Subgroup | No of studies | I2 (P) | HR (95% CI) | P |
|---|---|---|---|---|---|
| CD3+ TILs | CM | 3 | 51% (0.130) | 0.93 (0.27–3.15) | 0.906 |
| UM | 1 | 5.5 (N/A- N/A) | 0.03 | ||
| M | 4 | 28.4% (0.241) | 0.55 (0.4–0.77) | <0.001 | |
| CD4+ TILs | CM | 1 | 0.22 (0.09–0.55) | 0.001 | |
| UM | 1 | 0.80 (0.50–1.27) | 0.346 | ||
| M | 4 | 55.6% (0.080) | 0.60 (0.37–0.97) | 0.039 | |
| CD8+ TILs | CM | 2 | 0.0% (0.352) | 0.38 (0.19–0.75) | 0.005 |
| M | 5 | 50.4% (0.089) | 0.53 (0.37–0.75) | <0.001 | |
| FOXP3+ TILs | CM | 4 | 0% (0.785) | 0.58 (0.36–0.95) | 0.032 |
| UM | 1 | 1.14 (0.68–1.91) | 0.617 | ||
| M | 4 | 47.6% (0.126) | 0.45 (0.28–0.73) | 0.001 | |
| CD20+ TILs | CM | 1 | 0.42 (0.06–2.91) | 0.380 | |
| M | 2 | 0% (0.456) | 0.49 (0.34–0.72) | <0.001 |