Figure 1.

Changes in protein concentrations of circulating exosomes for HNSCC patients prior to and during therapy. (a): A decrease in plasma exosome protein concentrations in plasma is seen between baseline and weeks 5 and 14 in patients who remained disease free, while an increase is evident for patients whose disease progressed. (b): Individual exosome protein levels are shown for patients who progressed (n = 5) and those who did not (n = 13). Only patients with recurrent disease showed an overall increase in exosome protein levels during therapy (p < 0.05). Exosome protein levels decreased in patients who did not progress at week 5 (p < 0.005) and remained low at week 14 (p < 0.05) relative to baseline values. At week 14, patients who recurred had significantly higher exosome protein levels in plasma than patients who did not recur (p < 0.05). *p < 0.05 or **p < 0.005. In A the data are presented as mean values with connecting lines and error bars. In (b and c) and Figure 3–6, the data are presented as boxplots.