Figure 1.

LAMA4 is involved in the development of glaucoma by regulating the MAPK signaling pathway. A and B, heat maps of DEGs in glaucoma expression profiles, abscissa represented sample number, ordinate represented gene; the above dendrogram represented cluster type of sample; the red and blue stripes in the top represented type of sample, the left dendrogram represented gene clustering, each block represented expression of one gene in one sample, different colors represented different expressions; the color gradation represented gene expression, red represented high expression, blue represented low expression. C, Venn analysis of DEGs, blue represented the first 30 DEGs in GSE9944, red represented the first 30 DEGs in GSE2378, numbers represented the amount of genes in each block, the middle block represented the intersection of two profiles. D, association analysis between DEGs and glaucoma-related genes, each circle represented a gene, the word in circle represented GeneSymbol, black represented known disease gene, red represented DEGs in profile analysis; the size and color of the circle represented the importance of gene, the larger and brighter the circle was, the more important the gene was. LAM4, laminin α4; MAPK, mitogen-activated protein kinase; DEGs, differentially expressed genes.