Figure 1.

Human melanoma cell lines exhibit differential sensitivity to T-VEC-mediated lysis in vitro. Cells (5 × 10³) were seeded on 96-well plates and treated with T-VEC at the indicated multiplicity of infection (MOI) and MTS assay performed on day 5 post T-VEC infection to measure cell viability of (A) SK-MEL-2 (B) SK-MEL-5 (C) SK-MEL-28 (D) M14 and (E) LOX-IMVI at 5 days post T-VEC treatment. (F) Cell viability at 5 days post 0.3 MOI T-VEC treatment for selected cell lines. Each experiment was performed two or more times and similar results were obtained. Data are presented as mean ± SEM, and statistical differences between groups were measured by one way ANOVA. **p < 0.01, ***p < 0.001, ****p < 0.0001.