Figure 3.

Urelumab does not increase daratumumab-mediated ADCC in culture (a) Urelumab does not increase direct ADCC effects exerted by NK cells cultured as in Figure 2(a), that was measured as the % of MM1S-GFP-Luc dead cells at 1:1 E:T ratio. (b) Percentage of NK cells expressing CD16 when cultured as in Figure 2(a). (a and b) include results from seven different donors. (c) Surface CD107a expression on NK cells cultured as in Figure 2(a) corresponding to five different healthy donors. * = p < 0.05, ** = p < 0.01 and *** = p < 0.001 in a paired t-Test or one-way ANOVA test.