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. 2019 Apr 14;18(8):889–897. doi: 10.1080/15384101.2019.1598726

Figure 4.

Figure 4.

FENDRR inhibits survivin expression in SETDB1-dependent manner. (a): RNA pull-down and RIP assay were performed to determine whether FENDRR can combine with SETDB1. (b): The expression of SETDB1 and H3K9me1 in CCA tissues and paired adjacent non-cancerous tissues were measured by western blotting. (c): The expression of SETDB1 and H3K9me1 in normal cholangiocytes HIBEC cells and CCA cell lines were measured by western blotting. (d): The effect of SETDB1 on survivin and H3K9me1 expression in HuCCTl and QBC939 cells were determined by western blotting. (e): ChIP analysis of SETDB1 binding to the survivin promoter in CCA cell after transfection with FENDRR. (f): The effect of SETDB1 knockdown on survivin and H3K9me1 expression in HuCCTl and QBC939 cells after transfection with FENDRR were determined by western blotting. (*p < 0.05 vs. vector).