Figure 3.

LTX-401 treatment of subcutaneous MCA205 fibrosarcoma induces limited abscopal effects. C57BL/6 mice were inoculated with murine fibrosarcoma MCA205 subcutaneously on one side and four days later on the contralateral flank. Palpable primary tumors arising from the first injection were treated with sequential intratumoral injections of 0.25 mg LTX-401 as indicated in (A). LTX-401 induced efficient oncolysis in primary tumors which is reflected in reduced tumor growth and tumor clearance in some animals (B). In parallel tumors arising from untreated secondary lesions were monitored and abscopal effects were documented as tumor growth in separate curves (C). Lung cancer TC-1 cells were injected subcutaneously into C57BL/6 mice on one flank and four days later on the contralateral side. Palpable primary tumors arising from the first injection were treated with sequential injections of 0.25 mg LTX-401 intratumorally as indicated in (A). LTX-401 induced efficient oncolysis in primary tumors which is reflected in reduced tumor growth and tumor clearance in some animals (D). In parallel tumors arising from untreated secondary lesions were monitored and abscopal effects were documented as tumor growth curves (E).