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. 2019 Apr 11;8(7):1593802. doi: 10.1080/2162402X.2019.1593802

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 11. — The KIT-dependent mast cell signature is focally enriched in KRAS-mutant lung adenocarcinoma.

Pre-ranked gene set enrichment analysis of the humanized KIT-independent (left) and KIT-dependent (right) mast cell (MC) signatures from Figure 9D against 40 lung adenocarcinoma (LADC) tissues from never-smokers, 40 LADC tissues from smokers, 15 EGFR-mutant LADC, and 22 KRAS-mutant LADC from the Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) study [Gene Expression Omnibus (GEO) datasets GSE43458 and GSE31852; freely available at https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE43458 and https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE31852].^53,55,56 GSEA was performed with the Broad Institute pre-ranked GSEA module software (http://software.broadinstitute.org/gsea/index.jsp).⁶⁵ Normal lung tissue from 40 never smokers were used as controls (GSE31852). Note that using stringent cut-offs of both false discovery rate (FDR) q values <0.05 and family-wise error rate (FWER) probability (P) values <0.05 the KIT-dependent MC signature is focally enriched in the molecular signature of KRAS-mutant LADC (red fonts). Shown are enrichment plots, normalized enrichment scores (NES), FDR, and FWER values.