Table 8. Results from Bayesian latent class network meta-analysis in South Asia.
Sensitivity and specificity in pediatric patients compared with a blood culture reference test or theoretical bone marrow culture test.
| Diagnostic accuracy against blood culture | Diagnostic accuracy against latent class bone marrow culture | |||
|---|---|---|---|---|
| Test | Sensitivity (95%CI) | Specificity (95%CI) | Sensitivity (Scenario min-max) | Specificity (Scenario min-max) |
| Enterocheck WB IgM | 85% (73% - 93%) | 89% (85% - 92%) | 37% (28% - 54%) | 97% (96% - 98%) |
| ELISA IgA | 91% (79% - 98%) | 79% (70% - 86%) | 69% (53% - 83%) | 86% (84% - 91%) |
| ELISA IgG | 59% (45% - 72%) | 71% (65% - 77%) | 50% (44% - 54%) | 74% (70% - 77%) |
| ELISA IgM | 75% (62% - 86%) | 78% (72% - 83%) | 57% (48% - 64%) | 91% (89% - 92%) |
| ELISA IgG or IgM | 74% (56% - 87%) | 80% (74% - 85%) | 43% (35% - 58%) | 91% (88% - 94%) |
| Lateral flow IgG | 98% (90% - 99%) | 78% (68% - 86%) | 92% (72% - 98%) | 94% (92% - 85%) |
| Lateral flow IgG or IgM | 69% (57% - 79%) | 71% (65% - 76%) | 57% (47% - 65%) | 89% (88% - 91%) |
| TUBEX IgM | 63% (50% - 75%) | 84% (81% - 88%) | 44% (36% - 53%) | 94% (91% - 97%) |
| Typhidot IgG | 13% (4% - 30%) | 33% (26% - 40%) | 36% (21% - 48%) | 66% (63% - 68%) |
| Typhidot IgM | 77% (70% - 83%) | 60% (56% - 65%) | 75% (65% - 80%) | 94% (90% - 98%) |
| Typhidot IgG or IgM | 65% (44% - 83%) | 66% (50% - 80%) | 79% (76% - 91%) | 90% (88% - 92%) |
| Reverse passive Hemagglutination | 100% (93% - 100%) | 76% (66% - 84%) | 99% (98% - 100%) | 84% (83% - 86%) |
| Diazo method | 87% (69% - 96%) | 86% (77% - 93%) | 58% (45% - 74%) | 96% (94% - 97%) |
| Nested PCR | 44% (34% - 55%) | 83% (78% - 88%) | 39% (33% - 43%) | 94% (92% - 95%) |
| PCR | 48% (27% - 69%) | 84% (76% - 90%) | 33% (29% - 38%) | 86% (81% - 89%) |
| TPT Test | 100% (94% - 100%) | 69% (62% - 75%) | 90% (72% - 99%) | 93% (91% - 94%) |
| Widal slide (O, 1:80) | 71% (63% - 78%) | 98% (93% - 100%) | 60% (54% - 65%) | 99% (99% - 100%) |
| Widal slide (H, 1:80) | 86% (79% - 91%) | 98% (93% - 100%) | 76% (68% - 82%) | 99% (99% - 100%) |
| Widal slide (O or H, 1:160) | 74% (65% - 81%) | 68% (62% - 74%) | 66% (59% - 72%) | 86% (82% - 88%) |
| Widal tube (O, 1:80) | 57% (49% - 65%) | 74% (66% - 80%) | 54% (41% - 65%) | 76% (72% - 77%) |
| Widal tube (O, 1:160) | 70% (51% - 85%) | 94% (83% - 99%) | 48% (39% - 57%) | 98% (97% - 99%) |
| Widal tube (H, 1:160) | 30% (15% - 49%) | 98% (89% - 100%) | 18% (15% - 21%) | 99% (98% - 99%) |
| Widal (O or H, 1:80) | 92% (75% - 99%) | 100% (29% - 100%) | 72% (68% - 75%) | 91% (90% - 94%) |
| Widal (O 1:100 or H 1:200) | 30% (15% - 49%) | 91% (83% - 96%) | 19% (15% - 22%) | 96% (94% - 97%) |