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. Author manuscript; available in PMC: 2019 May 20.
Published in final edited form as: Annu Rev Cancer Biol. 2017 Mar;1:19–39. doi: 10.1146/annurev-cancerbio-041816-122338

Table 1.

Genetically engineered mouse models for studying autophagy deficiency in cancer

Cancer type Genotype Autophagy gene deleted Initiation Progression or tumor growth Metabolic consequences Reference
Pancreas Pdx1Cre; lslKrasG12D/+; Trp53flox/+ Atg5 Increased Decreased Decreased OCR Yang et al. 2014
Pancreas Pdx1Cre; lslKrasG12D/+ Atg5
Atg7 		Increased Decreased ND Rosenfeldt et al. 2013
Pancreas Pdx1Cre; lslKrasG12D/+; Trp53flox/flox Atg5
Atg7 		Increased Increased Increased glycolysis and PPP Rosenfeldt et al. 2013
Lung lslKrasG12D/+ Atg7 ND Decreased ND Guo et al. 2013a
Lung lslKrasG12D/+; Trp53flox/flox Atg7 ND Decreased Decreased FAO; increased glycolysis Guo et al. 2013a
Lung lslKrasG12D Atg5 Increased Decreased Decreased OCR Rao et al. 2014
Lung lslKrasG12D; Trp53flox/flox Atg5 No difference No difference ND Rao et al. 2014
Lung BrafV600E; Tp53flox/flox Atg7 Increased Decreased Decreased OCR Strohecker et al. 2013
Lung fsfKrasG12D; Tp53frt/frt Atg7 No difference Decreased ND Karsli-Uzunbas et al. 2014
Breast MMTV-PyMT FIP200 Decreased Decreased Decreased glycolysis Wei et al. 2011
Breast Palb2flox/flox; Wap-cre Becn1 ND Decreased ND Huo et al. 2013
Breast Palb2flox/flox; Trp53flox/flox; Wap-cre Becn1 ND No difference ND Huo et al. 2013
Melanoma TgTyr-cre/ERT2/+; Lsl-BrafV600E/+; Ptenflox/+ Atg7 Decreased Decreased ND Xie et al. 2015
Prostate Nkx3.1CreERT2/+; Ptenflox/flox Atg7 No difference Decreased ND Santanam et al. 2016
Colon VilCre-ERT2 Apcflox/+ Atg7 Decreased Decreased ND Lévy et al. 2015

Abbreviations: Atg, autophagy-related; Becn, Beclin; FAO, fatty acid oxidation; flox, conditional allele using the Cre-Lox system; frt, conditional allele using FLP-FRT system; fsf, frt-stop-frt; lsl, lox-stop-lox; ND, not determined; OCR, oxygen consumption rate; PPP, pentose phosphate pathway.