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. 2018 Aug 19;13(1):13–22. doi: 10.1080/19336918.2018.1491234

Table 1.

Regulation of glycosyltransferases in cancer. Glycosyltransferases upregulated or downregulated on cancer.

  Enzyme Regulation
Sialyltransferases ST3GAL1 ST3GAL3, ST3GAL4, ST3GAL6, ST6GAL1, ST6GALNAC1, ST6GALNAC2 ST8SIA1 Up-regulated
ST3GAL3, ST3GAL 4 ST3GAL6, ST6GALNAC Down-regulated
Fucosyltransferases FUT1, FUT2, FUT3, FUT4, FUT5, FUT6 FUT7 FUT8
FUT9, FUT10 FUT11
Up-regulated
FUT3, FUT4, FUT9, FUT10 Down-regulated
Others - Glucosaminyl (N-acetyl) transferase (GNT1)
- N-Acetylgalactosaminyltransferase 14 (GALNT14)
- β-1,4-galactosyltransferase 1–2-3–5 (B4GALT)
- Mannosyl (β1,4-)-glycoprotein β-1,4-N-acetylglucosaminyltransferas (MGAT3)
- Mannosyl (alpha-1,6-)-glycoprotein β −1,6-N-acetyl-glucosaminyltransferase (MGAT5)
Up-regulated
- Mannosyl (β1,4-)-glycoprotein β-1,4-N-acetylglucosaminyltransferas (MGAT3) Down-regulated