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Effect of atypical PKC inhibitors on normal and malignant colorectal cells. CCD18CO, LoVo, and RKO cells (4 x103) were plated in 96 wells plate and treated with 5 μM and 7 μM of either ICA-I or ζ-Stat for 72 hours followed by incubation with a WST-1 reagent for 3 hours and determination of absorbance at 450 nm using microplate reader. The data represents N = at least 3 independent experiments, mean ± S.E.M. *** < 0.0009, and **** < 0.0001 (indicate p value).
