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. 2019 Jun;95(6):629–637. doi: 10.1124/mol.118.115386

Fig. 4.

Fig. 4.

Treatment of RASMCs with FoxO inhibitor drug AS1842856 shows decrease in sGC mRNA, and protein expression occurs rapidly. Quantitative reverse-transcription PCR of 1 μM FoxO inhibitor treatment of 12, 24, and 48 hours on sGC α mRNA expression (A) or sGC β mRNA expression (B). (C) Western blot and quantification of 1 μM FoxO inhibitor treatment of 12, 24, and 48 hours on sGC α protein expression (D) and sGC β protein expression (E). n = 3 for all samples. One-way ANOVA test was used for determination of significance. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. Error bars represent S.D.