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. Author manuscript; available in PMC: 2019 May 21.
Published in final edited form as: Horm Behav. 2019 Jan 17;111:96–104. doi: 10.1016/j.yhbeh.2019.01.002

Figure 2.

Figure 2.

Infusion of flutamide into the dorsal hippocampus of intact males impaired memory consolidation in both tasks. (a) In the object placement task, mice infused with vehicle (n = 12) or 0.5 μg/hemisphere flutamide (n = 8) spent significantly more time with the moved object than chance (*p < 0.05). However, mice infused with 0.25 μg/hemisphere (n = 11) or 1.0 μg/hemisphere (n = 10) flutamide spent no more time than chance with the moved object, suggesting impairing effects of these doses. Mice infused with 1.0 μg/hemisphere flutamide also spent significantly less time with the moved object than those treated with vehicle (&p < 0.05). (b) In the object recognition task, mice infused with vehicle (n = 10), 0.25 μg/hemisphere (n = 8), or 0.5 μg/hemisphere (n = 9) of flutamide interacted with the novel object significantly more than chance (*p <0.05), whereas the mice treated with 1.0 μg/hemisphere flutamide (n = 9) did not. As in object placement, the time spent with the novel object differed significantly between mice treated with vehicle and 1.0 μg/hemisphere flutamide (&p < 0.05).