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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2018 Nov 24;1865(7):1938–1945. doi: 10.1016/j.bbadis.2018.10.042

Figure 4. EWSR1 plays an epigenetic role in the regulation of autophagy via a posttranscriptional modulation of UVRAG level.

Figure 4.

(i) EWSR1 deficiency increases the abnormal processing of pri-miRNAs to pre-mir125a and pre-mir351 by Drosha in the nucleus compartment. (ii) Next, elevated mature miRNA products (miR125a and miR351) degrade Uvrag mRNA in the cytoplasmic compartment. (iii) As a result, impaired UVRAG-dependent autolysosomal pathway leads to autophagy and cellular dysfunction. This figure is adopted from Autophagy (2015) 11 (5):796–811.