Skip to main content
. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Pain. 2019 Jun;160(6):1245–1260. doi: 10.1097/j.pain.0000000000001519

Fig.4. CBP have weaker functional connectivity to the medial prefrontal cortex.

Fig.4

Whole brain seed-to-voxel resting state functional connectivity in four datasets (n=156) of the right anterior hippocampus (antHC) seed in CBP patients compared to healthy participants. Patients had weaker functional connectivity between the right antHC the medial prefrontal cortex, including the bilateral pregenual anterior cingulate cortex and the left medial frontal pole, compared to healthy participants (cluster-size PFWE < 0.05, with a cluster-forming height threshold of p< 0.001). Functional connectivity strength (mean ± SD) is represented for both patients with chronic low back pain and healthy participants. Significant clusters are shown on a semi-inflated MNI brain in CONN. Abbreviations: antHC anterior hippocampus, CBP chronic low back pain patients, mFP medial frontal pole, pACC pregenual anterior cingulate cortex.