Skip to main content
. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Mol Neurobiol. 2018 Nov 20;56(7):5032–5040. doi: 10.1007/s12035-018-1430-0

Figure 5. PRF-P induces microenvironmental changes reducing the Tregs migration toward GL261 cells.

Figure 5.

The mRNA level for chemokine (C-C motif) ligand a. 2 and b. 22 (CCL2 and CCL22, respectively) was significantly reduced by the PRF-P treatment in GL261-Treg co-culture (n=3). c. PRF-P caused cessation of the Treg migration after pharmacological blockade of the CCL2/22 interaction with their receptors (n=3). d. Pharmacological inhibition of the soluble CD40 ligand (sCD40L) reversed the PRF-P induced reduction of the Tregs’ migration (n=3).