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. 2019 Apr 26;145(6):1495–1507. doi: 10.1007/s00432-019-02920-4

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — The efficacy of CUSP9 combination in a heterogeneous GSC culture population. a, b The efficacy of CUSP9 w/TMZ in up to a total of 15 GSC cultures from both primary and recurrent GBM evaluated by viability and cytotoxicity, respectively. c Ranked correlation (spearman) of sensitivity to CUSP9 from the viability and cytotoxicity evaluation. d, e The efficacy of the CUSP9 combination in all GSC cultures compared to TMZ monotherapy (p < 0.0001, paired sample t test). f Representative images of sphere formation in the recurrent GSC culture T1544 display the resistance to TMZ and sensitivity to CUSP9. Scale bar 500 µm