Table 3.
Other representative analysis results of MUSIC
| Datasets | Technology | Demonstrated perturbation | Output | Original study | MUSIC |
|---|---|---|---|---|---|
| Mouse myeloid cell (GSE90486) | CRISP-seq6 | Cebpb | Overall perturbation effect | — | Rank 1st |
| Topic-specific functional perturbation effect | Immune cell differentiation |
• Immune cell differentiation24 • Cell migration22 |
|||
| Perturbation relationship | — | cor(Cebpb,Rela) = 0.9925 | |||
| Human MCF10A cell (treated with doxorubicin, GSM2911346) | Updated version of CROP-seq8 | TP53 | Overall perturbation effect | — | Rank 1st |
| Topic-specific functional perturbation effect | DNA replication | DNA replication37 | |||
| Perturbation relationship | — | cor(TP53, MLH1) = 0.99 | |||
| Human Jurkat cell (stimulated by anti-CD3/CD28, GSM2439086~GSM2439090) | CROP-seq7 | LCK | Overall perturbation effect | — | Rank 6th |
| Topic-specific functional perturbation effect | TCR signature | leukocyte differentiation | |||
| Perturbations Relationship | LCK, ZAP70, LAT have similar effect on TCR activation signature. |
cor(LCK, ZAP70) = 0.93 cor(LCK, LAT) = 0.50 cor(ZAP70, LAT) = 0.78 |
cor(a,b) represents the Pearson correlation coefficient of topic distribution between perturbation a and perturbation b