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. 2019 May 14;10:1072. doi: 10.3389/fimmu.2019.01072

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Copyright © 2019 Vaccari, Fourati, Brown, Silva de Castro, Bissa, Schifanella, Doster, Foulds, Roederer, Koup, Sui, Berzofsky, Sekaly and Franchini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Heatmap showing log2-fold change (post-vaccination—pre-vaccination) in B cell pathways that are negatively correlated with HLA-DR⁻ CD14⁺ cell frequency and also correlated with protection from SIV acquisition. (B,C) Sample enrichment analysis was used to summarized per sample the expression of genes part of the B cell pathway. The scatter plots shows the frequencies of HLA-DR⁻CD14⁺ cells as a function of the B cell pathway measured 24 h after the 2nd boost (B) and the B cell pathway as a function of the NO pathway (C). The size of the dots is proportional to the number of SIV challenge to infection of the vaccinated animals. A Spearman correlation and t-test was used to test the correlation is different from 0.