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. 2019 May 14;10:1068. doi: 10.3389/fimmu.2019.01068

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Copyright © 2019 Ivetic, Hoskins Green and Hart.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Different glycoforms of O-linked sialyl Lewis X (sLex). sLe^x can exist in multiple configurations: extended core 1, core 2, or both (biantennary). Sulfotransferases can attach sulfate esters to Gal or GlcNAc, respectively at positions 6 or 6′. Sulfates can be added to sLe^x one or both positions in either extended core 1, core 2, or the biantennary configuration. Recognition of the MECA-79 epitope is provided in the biantennary structure, but can exist in any of the 3 glycoforms. N-linked sLex has also been shown to act as bonafide L-selectin ligands, but are not depicted in this figure. More information can be found in a short concise commentary (177). The glycoforms are drawn in accordance with GlycanBuilder (178). S/T = serine/threonine.