Table 1.

Activation of mitochondrial biogenesis via Nrf2/ARE signal pathway.

Activation of Nrf2	Organ or cell line	Physiological condition	References
CO-stimulated H2O2 production	Heart	Non-diseased	Piantadosi et al., 2008
H2S	Heart	Heart failure	Calvert et al., 2010
CO	Liver	Staphylococcus aureus-caused sepsis	MacGarvey et al., 2012
Acetyl-L-carnitine	Brain	Hypoxia	Hota et al., 2012
Dimethyl fumarate	Brain	MPTP-induced Parkinson’s disease	Ahuja et al., 2016
Quercetin	Brain	Traumatic brain injury	Li et al., 2016
Methylene blue	Brain	Non-diseased mid-aged mice	Gureev et al., 2016
Physical exercise	Brain	6-OHDA-induced Hemiparkinsonism	Aguiar et al., 2016
Grape powder	Kidney	Non-diseased mid-aged rats	Pokkunuri et al., 2016
Physical exercise	Skeletal muscle	Non-diseased	Merry and Ristow, 2016
PNU282987	Glial cells	Non-diseased	Navarro et al., 2017
Sulforaphane	Cells LLCPK1 and PC3	Prostate cancer	Negrette-Guzmán et al., 2017
Physical exercise	Skeletal muscle	Non-diseased	Zoladz et al., 2017
Nox4 downregulation	Lung Fibroblasts	Non-diseased	Bernard et al., 2017
Dimethyl fumarate	Peripheral blood lymphocytes	Multiple sclerosis	Hayashi et al., 2017
Acute effect of severe burn trauma	Liver	Burn trauma	Bohanon et al., 2018
β-Guanidinopropionic acid	Brain	Mid-aged mice	Gureev et al., 2018