Fig. 1.

Characteristics of the fRPE transcriptome. a Multidimensional scaling against GTEx tissues locates fRPE near heart, skeletal muscle, and brain samples. b A subset of the fRPE-selective gene set defined by z-score >4 is shown including RPE signature genes such as RPE65 and new genes such as TYR. Red/pink dots indicate fRPE-selective genes with z-score >4 in both glucose and galactose conditions. c, d Two examples of the expression levels of fRPE-selective genes in various GTEx tissues. Only the top 25 tissues are plotted for visual clarity. For a, c, and d, red indicates fRPE glucose condition and blue indicates fRPE galactose condition. For c and d, each element of the boxplot is defined as follows: centerline, median; box limits, upper and lower quartiles; whiskers, 1.5× interquartile range