Fig. 1.

Clinical scores and body weights. Clinical scores (A) and body weights (B) were recorded for both CFA and EAMG rats every other day after the first immunization. Mild clinical signs occurred ~10 days after the first immunization. Clinical manifestations of EAMG then gradually became evident 7 days after the second immunization. Arrows indicate immunization time-points. In contrast, rats in the CFA group showed no clinical signs of EAMG or any abnormal weight loss. Data are from two independent experiments with 6 rats per condition per experiment (*P < 0.05, ***P < 0.001).