Fig. 2.

Network connectivity analysis. The PRE of genes were loaded as attributes in a protein interactome. In the central panel, genes with a PRE above the 95th percentile of their respective cell-specific distributions are visualized (M: monocyte, green; T: T cells, red; B: B cells, blue, C: CNS, yellow). For each cell type, the number of edges in the sub-network composed of interacting proteins with PRE above the threshold was analyzed. In this example, the CNS sub-network is composed of 109 nodes and 71 edges. Ten thousand random networks with the same number of nodes (i.e. 109) were generated and the distribution of edges was plotted along with the number of edges of the relevant sub-network (i.e. 71). A p-value was computed to evaluate the probability that this number of edges was seen by chance