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. 2019 May 20;6:65. doi: 10.1038/s41597-019-0071-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Identification of tissue-specific chromatin accessible elements and transcription factors. (a) Heatmap clustering showing the tissue-specific accessible elements. (b) Enrichment of the indicated TF motifs in each tissue. The size and color of each point represent the motif enrichment P-value (−log10 P-value). (c) The hierarchical clustering of transcription factor enrichment scores in each tissue. Euclidian distances are shown in the legend.