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. 2019 May 20;9:7617. doi: 10.1038/s41598-019-44098-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FAK/Pyk2 activity controls vascular inflammation in vivo mouse carotid ligation model. Ligated carotid arteries from 8-week-old ApoE−/− mice were harvested after fed a high fat diet (HFD) for 1 week with or without PF-271. Normal arteries from ApoE−/− mice fed with normal chow were used as control. (a) Sections were stained with VCAM-1 (red), vWF (green), and DAPI (blue). Scale bar (20 μm). (b) Macrophage infiltration was monitored with anti-CD68 (red) staining. Anti-α-SMA (green) and DAPI (blue) were used as counterstain. Scale bar (20 μm). (c) FAK activity was evaluated by staining anti-pY576/577 FAK (red). Anti-α-SMA (green) and DAPI (blue) were used as counterstain. Scale bar (20 μm). (d) Cropped images of immunoblotting of lung lysates of active FAK (pY397 FAK), total FAK, and β-actin as loading control are shown. Full length blots shown in Supplemental Fig. 14.