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. 2019 May 14;10:1038. doi: 10.3389/fmicb.2019.01038

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Copyright © 2019 Hakeem, Asseri, Ma, Chou, Konkel and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Predicted example of combining two antimicrobials based on their sub-MICs. Inhibitory effect represents the percentage of inactivated cells. Increasing the concentration in the hyperbolic curve from 50 to 100 ppm raises the inhibitory effect by 5% (from 85 to 90%). Increasing the concentration in the sigmoidal curve from 50 to 100 ppm raises the inhibitory effect by more than 3-fold (from 18 to 88%).