. 2019 May 14;10:481. doi: 10.3389/fphar.2019.00481

Table 4.

Cox proportional hazard regression results for incidence of grade 3 or 4 hematologic toxicity.

Parameters	Univariate analysis		Multivariate analysis
	^†OR (95% CI)	p-value	Model 1		Model 2
			OR (95% CI)	p-value	OR (95% CI)	p-value
Body surface area
<1.5	1
1.5–1.75	0.68 (0.45–1.04)	0.07
>1.75	1.03 (0.62–1.72)	0.91
Cardiovascular co-morbidity
No	1
Yes	0.56 (0.27–1.14)	0.11
HIV/AIDS
No	1
Yes	0.62 (0.30–1.26)	0.19
Baseline leukocyte toxicity grade
Normal^‡	1		1
Grade 1^£	3.20 (2.02–5.08)	< 0.001	2.75 (1.47–5.15)	< 0.001
Baseline neutrophil toxicity grade
Normal‡	1				1
Grade 1^§ or Grade 2^¥	2.32 (1.58–3.41)	< 0.001			2.75 (1.73–4.35)	< 0.001
*CYP3A5*
^∗1/^∗1	1		1		1
^∗3 carriers	2.34 (1.03–5.32)	0.042	2.04 (0.87–4.79)	0.05	2.12 (0.90–4.96)	0.08
*CYP2C9*
^∗1/^∗1	1		1		1
^∗2 or ^∗3 carriers	0.35 (0.14–0.88)	0.024	0.40 (0.13–1.18)	0.10	0.49 (0.19–1.22)	0.12
*CYP2C19*
^∗1/^∗1	1
^∗2 or ^∗3 carriers	1.08 (0.76–1.54)	0.66
*CYP2J2*
^∗1/^∗1	1		1		1
^∗7 carriers	1.66 (1.05–2.64)	0.032	1.82 (1.14–2.9)	0.012	1.74 (1.09–2.78)	0.021
*POR*
^∗1/^∗1	1
^∗28 carriers	0.95 (0.58–1.56)	0.83
*ABCB1 rs 3842 A>G*
AA	1
G carriers	0.75 (0.35–1.62)	0.46

^†Odds ratio; ^‡4,500–10,000/m³; ^£3,000–4,500/mm³; ^d'2,500–7,500/m³; ^§1,500–2,500/m³; ^¥1,000–1,500/m³.