Table 2.
Univariate and multivariate Cox regression analysis based on all variables for cancer-specific survival (Training Cohort).
| Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| AGE | ||||
| <65 | Reference | Reference | ||
| ≥65 | 1.638 (1.077–2.489) | 0.021 | 2.722 (1.720–4.306) | <0.001 |
| RACE | ||||
| White | Reference | Reference | ||
| Black | 1.859 (1.183–2.921) | 0.007 | 1.377 (0.845–2.244) | 0.199 |
| Other | 1.231 (0.498–3.044) | 0.652 | 0.907 (0.356–2.309) | 0.838 |
| MARITAL STATUS | ||||
| Married | Reference | Reference | ||
| Unmarried | 1.442 (0.963–2.159) | 0.076 | 1.453 (0.940–2.248) | 0.093 |
| Unknown | 1.040 (0.450–2.406) | 0.926 | 1.473 (0.625–3.473) | 0.376 |
| HISTOLOGY | ||||
| Ductal | Reference | Reference | ||
| Lobular | 1.521 (0.212–10.926) | 0.676 | 3.154 (0.430–23.158) | 0.259 |
| Mixed ductal and lobular | 0.908 (0.224–3.686) | 0.893 | 0.653 (0.157–2.722) | 0.558 |
| Others | 1.479 (0.686–3.186) | 0.318 | 1.558 (0.703–3.453) | 0.275 |
| GRADE | ||||
| I | Reference | Reference | ||
| II | 1.107 (0.489–2.509) | 0.807 | 0.631 (0.270–1.477) | 0.289 |
| III | 3.556 (1.632–7.748) | 0.001 | 1.722 (0.752–3.941) | 0.198 |
| IV | – | 0.976 | – | 0.996 |
| AJCC STAGE | ||||
| I | Reference | Reference | ||
| II | 2.479 (1.238–4.965) | 0.010 | 2.280 (1.120–4.639) | 0.023 |
| III | 6.169 (3.091–12.312) | <0.001 | 6.090 (2.909–12.750) | <0.001 |
| IV | 31.747 (16.138–62.455) | <0.001 | 21.310 (9.698–46.815) | <0.001 |
| ER STATUS | ||||
| Positive | Reference | Reference | ||
| Negative | 8.522 (4.746–15.303) | <0.001 | 2.956 (1.361–6.419) | 0.006 |
| PR STATUS | ||||
| Positive | Reference | Reference | ||
| Negative | 3.004 (1.862–4.846) | <0.001 | 1.825 (1.000–3.328) | 0.049 |
| HER2 STATUS | ||||
| Positive | Reference | Reference | ||
| Negative | 0.622 (0.370–1.047) | 0.074 | 0.988 (0.565–1.728) | 0.967 |
| Borderline | 0.208 (0.028–1.560) | 0.127 | 0.336 (0.044–2.573) | 0.294 |
| SURGERY | ||||
| Performed | Reference | Reference | ||
| Not performed | 12.593 (8.011–19.795) | <0.001 | 3.563 (1.912–6.641) | <0.001 |
| RADIOTHERAPY | ||||
| Yes | Reference | Reference | ||
| No | 0.933 (0.612–1.425) | 0.749 | 1.351 (0.855–2.135) | 0.197 |
| CHEMOTHERAPY | ||||
| Yes | Reference | Reference | ||
| No | 0.688 (0.470–1.007) | 0.055 | 0.971 (0.624–1.509) | 0.894 |
AJCC, The American Joint Committee for Cancer; ER, Estrogen receptor; PR, Progesterone receptor; HER2, Human epidermal growth factor 2-neu.
The bold values represent statistical significance.