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. 2019 May 14;13:110. doi: 10.3389/fnbeh.2019.00110

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Copyright © 2019 Chen, Liu, Ma, Ma and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Optogenetic activation of ChR2 in accumbal Parvalbumin-positive (PV⁺) interneurons evoked conditioned place preference (CPP). (A,B) Virus injection and behavioral scheme. AAV₉-EF1α-DIO-mCherry (mCherry) or AAV₉-EF1α-DIO-ChR2-mCherry (ChR2) was infused into the NAcc of PV::Cre mice, and optical fiber was implanted in the nucleus accumbens core (NAcc). The mice were presented with daily conditioning trials for 3 days: one compartment paired with laser stimulation and the other compartment without laser stimulation. (C) Representative image of ChR2-mCherry expression in NAcc of PV::Cre mice. Scale bar: 200 μm. (D) Optogenetic activation of ChR2 in NAcc PV⁺ interneurons promoted CPP formation. mCherry, n = 20; ChR2, n = 10, ***p < 0.001 vs. Pretest group, ^##p < 0.01 vs. mCherry group. Data are expressed as mean ± standard error of the mean (SEM).