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. 2019 May 14;10:1062. doi: 10.3389/fimmu.2019.01062

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Copyright © 2019 Tuen, Bimela, Banin, Ding, Harkins, Weiss, Itri, Durham, Porcella, Soni, Mayr, Meli, Torimiro, Tongo, Wang, Kong, Nádas, Kaufmann, Brumme, Nanfack, Quinn, Zolla-Pazner, Redd, Finzi, Gorny, Nyambi and Duerr.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ADCC and IgA/IgG patterns. (A) Scatter plot analysis of Env-specific plasma IgA/IgG ratios (top) and ADCC (N-U-)(bottom) against HIV-1 ADA-infected CEM-NKR cells. Mean and standard deviation for the five longitudinal values per participant are shown. All statistically significant differences among participants are indicated (one-way ANOVA, ^*P < 0.05; ^**P < 0.005). (B,C) Correlation analysis between ADCC (N-U-) and Env-specific plasma IgA/IgG ratios using all data points (B) and means per participant and parameter (C). Correlation coefficients r (with 95% confidence intervals if applicable) and P-values are indicated using non-parametric Spearman rank. Asterisks indicate statistically significant correlations in a two-tailed (B) or one-tailed Spearman rank test (means) (C) (^*P < 0.05). ADCC, antibody-dependent cellular cytotoxicity; ART, antiretroviral treatment; N-U-, Nef- and Vpu-deficient.