Table 7.
Overview of genetic variations associated with asparaginase hypersensitivity.
| Gene | Variant | Ethnicity | Odds ratio | Study type | Cohort | Study |
|---|---|---|---|---|---|---|
| GRIA1 | rs4958351 (Intronic) |
Caucasian | 1.7 | Candidate gene study | 72 cases and 74 tolerant controls | (Rajić et al., 2015) |
| Hungarian | 0.05 | Candidate gene study | 66 cases and 398 tolerant controls | (Kutszegi et al., 2015) | ||
| rs4958381 (Intergenic) |
Multiethnic cohort | 1.8 | Candidate gene study | 204 cases and 281 tolerant controls | (Chen et al., 2010) | |
| rs4958676, rs6889909and rs6890057 (all intronic) |
Caucasian | 1.6 | Candidate gene study | 72 cases and 74 tolerant controls | (Rajić et al., 2015) | |
| rs10070447 (Intronic) |
Caucasian | 1.7 | Candidate gene study | 72 cases and 74 tolerant controls | (Rajić et al., 2015) | |
| rs2055083 (Intronic) |
Hungarian | 0.2 | Candidate gene study | 298 cases and 192 tolerant controls | (Kutszegi et al., 2015) | |
| rs707176 (I187I) |
Hungarian | 3 | Candidate gene study | 292 cases and 185 tolerant controls | (Kutszegi et al., 2015) | |
| HLA-DRB1 | rs17885382 (R54Q) |
Multiethnic cohort | 1.6 | GWAS | 589 cases and 2719 tolerant controls | (Fernandez et al., 2015) |
| HLA-DRB1*0701 | Multiethnic cohort | 1.6 | Candidate gene study | 363 cases and 1844 tolerant controls | (Fernandez et al., 2014) | |
| Hungarian | 2.9 | Candidate gene study | 321 cases and 38 tolerant controls | (Kutszegi et al., 2017) | ||
| ASNS | rs3757676 and rs3832526 (both intronic) |
Caucasian | 0.4 | Candidate gene study | 45 cases and 240 tolerant controls | (Ben Tanfous et al., 2015) |
| NFATC2 | rs6021191 (Intronic) |
Multiethnic cohort | 3.1 | GWAS | 589 cases and 2719 tolerant controls | (Fernandez et al., 2015) |