Table 2.
Epitopes targeted in donor MM and previously described HCV-specific CD8+ T cell epitopes restricted by the HLA class I alleles present in donor MM.
| HLA allele | Described HCV-specific epitopes (immunodominant epitopes in bold) | Epitopes targeted in donor MM (dominant responses in bold) | ||||
|---|---|---|---|---|---|---|
| A*01:01 | NS31436-1444 | ATDALMTGY | 9-mer | |||
| E2518-527 | TTDRSGAPTY | 10-mer | ||||
| A*26:01 | NS31383-1391 | EVIKGGRHL | 9-mer | NS31383-1393 | EVIKGGRHL-IF | 11-mer |
| NS31582-1590 | ENLPYLVAY | 9-mer | ||||
| NS3/4A1654-1662 | EVVTSTWVL | 9-mer | ||||
| NS5A/B2416-2424 | DVVCCSMSY | 9-mer | ||||
| NS31337-1347 | ETAGARLVVLA | 11-mer | ||||
| B*08:01 | NS31395-1403 | HSKKKCDEL | 9-mer | NS31395-1403 | HSKKKCDEL | 9-mer |
| NS31402-1410 | ELAAKLVAL | 9-mer | ||||
| NS31611-1618 | LIRLKPTL | 8-mer | ||||
| B*27:05 | P7780-788 | GRWVPGAAY | 9-mer | |||
| NS31492-1501 | GRGKPGIYRF | 10-mer | ||||
| NS5B2841-2849 | ARMILMTHF | 9-mer | NS5B2841-2849 | ARMILMTHF | 9-mer | |
| NS5B2936-2944 | GRAAICGKY | 9-mer | NS5B2936-2946 | GRAAICGKY-LF | 11-mer | |
| NS5A2131-2141 | HRFAPPCKP-LL | 11-mer | ||||
HCV, hepatitis C virus.